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Clinical Guide

THE POLYPHARMACY REVIEW FRAMEWORK

Updated June 25, 2026
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  • BAA available·
  • PHI never used for model training·
  • Built by a triple board-certified psychiatrist·
  • DSM-5-TR-informed reasoning·
  • Clinician-in-the-loop, always·
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The Polypharmacy Review Framework: How to Evaluate a Medication List Before Adding Another Medication

Polypharmacy rarely develops from a single decision. More often, it evolves gradually as medications are added over time without systematic reassessment. This practical framework provides a structured approach to reviewing medication regimens before introducing additional treatments. It guides clinicians through evaluating each medication's target, effectiveness, burden, and ongoing justification while identifying prescribing cascades, therapeutic duplication, and opportunities for simplification. Designed for clinicians and trainees, this guide emphasizes thoughtful medication review, functional outcomes, patient involvement, and intentional prescribing to ensure that every medication continues to earn its place in the treatment plan.

For educational purposes only. Not individual medical advice.